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Proof On Main Restaurant

4.5(2,082)
American Restaurant

About

Proof on Main, located inside the 21c Museum Hotel, blends contemporary Southern cuisine with a vibrant collection of Kentucky bourbons. The airy space features rotating contemporary art exhibitions that create a dynamic backdrop for business lunches and dinners.

The menu highlights locally sourced Appalachian ingredients with dishes like spicy Calabrian sausage paccheri and a well-balanced bison burger. A private dining room accommodates up to 24 guests, making it ideal for focused meetings or intimate receptions in a stylish, art-filled setting.

Best for

  • Client dinners with local Southern flair
  • Private dining for groups up to 24
  • Creative team lunches in art-filled space

Request a Package

Tell the venue what you're planning and they'll respond with a custom proposal within 1–2 business days.

Group Dining Event

Custom request

Perfect for team dinners, client lunches, and celebration meals. Reserve a private or semi-private space for your group with food, drinks, and AV if needed.

What's typically included

  • Private or semi-private space
  • Food & beverage
  • AV & technology

Happy Hour

Custom request

Host a relaxed evening reception for your team or clients. Reserve a space for drinks and light bites in a social, low-key setting.

What's typically included

  • Private or semi-private space
  • Food & beverage

Full Buyout

Custom request

Take over the entire restaurant for your event. Full control of the space, menu, and atmosphere — ideal for large celebrations or exclusive corporate events.

What's typically included

  • Full venue layout
  • Food & beverage
  • AV & technology

Venue Details

Standout features

Artistic Ambiance
Contemporary artwork integrated throughout the venue
Rotating exhibitions and site-specific installations from the adjoining 21c Museum Hotel create a vibrant, gallery-like atmosphere that distinguishes the space from typical restaurants.
Locally Sourced Southern
Southern and Appalachian-inspired farm-to-table menu
Dishes highlight regional producers and ingredients, offering creative, well-traveled flavors that reflect the Ohio River Valley’s culinary heritage.
Private Dining
Dedicated private dining room for groups up to 24
A customizable space for business luncheons or intimate dinners, featuring menus rich with local flavor crafted by the in-house chef team.

At a glance

Rated 4.5 on Google · 2,082 reviews